I think you should flesh out this concept more before presenting it wholesale. Lovecraftian by definition is an incredibly difficult setting to portray and write about (you can't really just spam "OOOOOOOO HEADACHES PURPLE GLOW!!!!!!") without having an actual standard base to set up. The reason why his work, well, works so well is that it has a base and foundation as to what it can and cannot do - you really need a grounded setting to actually portray helplessness, because otherwise what happens is you're just playing a soap drama. What is the hook, the power, the plantation, so to speak that we as a playerbase would need to push off from to combat the sensation of nothingness?